The Upstate SC Alliance, a public/private regional economic development organization, has compiled a list of the largest employers in the 10-county region.
These businesses encompass the health care, state and federal government, manufacturing, retail, education and utility sectors.
| Company | Employee Range | Line of Business |
| Prisma Health – Upstate | Over 5,000 | Health care system |
| State of South Carolina | 5,000 | State government |
| BMW | 5,000 | Automobile manufacturer |
| Greenville County Schools | Over 5,000 | K-12 public education |
| Spartanburg Regional Healthcare System | Over 5,000 | Health care system |
| United States Government | Over 5,000 | Federal government |
| Michelin North America | Over 5,000 | Tire manufacturing |
| Walmart | Over 5,000 | Retail stores and distribution |
| Clemson University | Over 5,000 | Public research university |
| Bon Secours St. Francis Health System | 2,501-5,000 | Health care system |
| Milliken & Company | 2,501-5,000 | Textiles, floor covering, performance materials and specialty chemicals |
| AnMed Health | 2,501-5,000 | Health care system |
| GE Power | 2,501-5,000 | Power generation, energy delivery and water process technologies |
| Duke Energy Corp. | 2,501-5,000 | Utility provider |
| Bi-Lo | 2,501-5,000 | Retail grocery stores |
| Greenville County | 2,501-5,000 | County government and administration |
| ZF Transmissions Gray Court LLC | 2,501-5,000 | Automatic transmissions manufacturer |
