John P. Erwin III joined Prisma Health as chair of internal medicine in the Upstate.
He also serves as chair of medicine for University of South Carolina School of Medicine Greenville.
Erwin served as the Department of Internal Medicine chair at Endeavor Health — Illinois’ third-largest health system. He also worked as clinical professor of medicine at The University of Chicago Pritzker School of Medicine and Texas A&M College of Medicine, internal medicine chair at Baylor Scott & White Health, clinical instructor with the Mayo School of Graduate Medical Education, Texas governor for the Texas chapter of the American College of Cardiology, and a core speaking faculty member for the American Heart Association’s National Speakers Bureau.
His research background is in hypertrophic cardiomyopathy and sports cardiology, as well as valvular heart disease and health care delivery science.
Erwin has served on the American College of Cardiology writing committee for Valvular Heart Disease since 2014. In 2025, he was recognized among his peers and awarded the Masters of the American College of Cardiology.
He is a graduate of Texas A&M University College of Medicine and Indiana University Kelley School of Business. He completed his medical residency and fellowship at Mayo Graduate School of Medicine.
