NEXT Upstate, an organization that supports innovators and their ventures, compiled a list of the top tech companies in its network.
All of the businesses, except Advoco, were established in Greenville.
| Company Name | Number of Employees | Date Established | Technology Produced |
| 6AM City | 53 | 2016 | Digital media newsletter production |
| Advoco | 115-200 | 2002 | EAM software consulting service |
| Base | 20-50 | 2018 | Executive assistant software |
| BringFido | 25-50 | 2005 | Mobile app connecting pet owners with places to stay, play and dine |
| ChartSpan | 102-200 | 2012 | Chronic care management and merit-based incentive payment system |
| GreenCloud Defense | 84-200 | 2011 | Cisco-powered infrastructure, VMware and Tintri |
| Immedion | 102-200 | 2007 | Cloud, data center and managed IT services provider |
| Kopis | 50 | 1999 | Customized software and cloud services |
| Mailprotector | 32-50 | 1999 | Cloud-based email security with data encryption |
| Netalytics | 55 | 1995 | Software designed specifically for opiate addiction treatment facilities |
| Rymedi | 21-50 | 2017 | Cloud-based digital workflow disease response |
| Stark RFID | 16-50 | 2004 | RFID integrator of customized real-time location systems |
| Zipit Wireless | 20-50 | 2007 | M2M, IoT connectivity and billing, and subscription platform |
